Protein Details: Potassium voltage-gated channel subfamily H member 5

Protein ID

ICDB_Pro_1284

Protein Name

Potassium voltage-gated channel subfamily H member 5

Gene Name

KCNH5; EAG2

Organism

Homo sapiens (Human)

Length

988 amino acids

AlphaFoldDB

AF-Q8NCM2-F1-model_v4.pdb

Function

Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a non-inactivating outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly

Sequence

MPGGKRGLVAPQNTFLENIVRRSSESSFLLGNAQIVDWPVVYSNDGFCKLSGYHRADVMQKSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEHEKVVLFLCTFKDITLFKQPIEDDSTKGWTKFARLTRALTNSRSVLQQLTPMNKTEVVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVVAILGKGDVFGDIFWKETTLAHACANVRALTYCDLHIIKREALLKVLDFYTAFANSFSRNLTLTCNLRKRIIFRKISDVKKEEEERLRQKNEVTLSIPVDHPVRKLFQKFKQQKELRNQGSTQGDPERNQLQVESRSLQNGASITGTSVVTVSQITPIQTSLAYVKTSESLKQNNRDAMELKPNGGADQKCLKVNSPIRMKNGNGKGWLRLKNNMGAHEEKKEDWNNVTKAESMGLLSEDPKSSDSENSVTKNPLRKTDSCDSGITKSDLRLDKAGEARSPLEHSPIQADAKHPFYPIPEQALQTTLQEVKHELKEDIQLLSCRMTALEKQVAEILKILSEKSVPQASSPKSQMPLQVPPQIPCQDIFSVSRPESPESDKDEIHF

PDB Structures

7YID 7YIE 7YIF 7YIG 7YIH 7YIJ

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

550..667

Disease

Developmental And Epileptic Encephalopathy 112 and Developmental And Epileptic Encephalopathy

Location

Detected in brain; skeletal muscle; heart; placenta; lung and liver; and at low levels in kidney.

DOI ID

10.1016/s0014-5793(02)02365-7; 10.1016/s0014-5793(02)03055-7; 10.1038/ng1285; 10.1038/nature01348; 10.1101/gr.2596504; 10.1002/pmic.200700887; 10.1111/epi.12201

RefSeq

NP_647479.2 [Q8NCM2-1]; NP_758963.1 [Q8NCM2-2]